| S2606 |
Mifepristone |
Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1. |
Selective |
Progesterone receptor, IC50: 0.2 nM |
| S3167 |
Altrenogest |
Altrenogest (A35957, RU2267,R2267) is a progestogen structurally related to veterinary steroid trenbolone. |
Selective |
|
| S2611 |
Ethisterone |
Ethisterone(17α-Ethynyltestosterone) is a progestogen hormone being considered to treat prostate cancer. |
Selective |
|
| S1727 |
Levonorgestrel |
Levonorgestrel (D-Norgestrel) is a female hormone that prevents ovulation. |
Selective |
|
| S1377 |
Drospirenone |
Drospirenone (ZK 3059) is a synthetic progestin that is an analog to spironolactone. |
Selective |
|
| S4097 |
Dydrogesterone |
Dydrogesterone (NSC 92336) is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus. |
Selective |
|
| S1914 |
Pregnenolone |
Pregnenolone(3β-Hydroxy-5-pregnen-20-one) is an endogenous steroid hormone, used in the treatment of fatigue, Alzheimer’s disease, trauma and injuries. |
Selective |
|
| S3081 |
Ulipristal Acetate (CDB 2914) |
Ulipristal acetate (CDB-2914, HRP 2000, RU 44675) is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure. |
Selective |
|
| S2567 |
MPA (Medroxyprogesterone acetate) |
MPA (Medroxyprogesterone acetate) is a synthetic progestin and act as a potent progesterone receptor agonist, used to treat abnormal menstruation or irregular vaginal bleeding. |
Selective |
|
| S3160 |
Ethynodiol diacetate |
Ethynodiol diacetate (8080 CB,Ethynodiol acetate) is one of the first synthetic progestogens used in contraceptive pills. |
Selective |
|
| s1251 |
Dienogest |
Dienogest (STS 557) is an orally active synthetic progesterone, used for contraception and the treatment of endometriosis. |
Selective |
|
| S1705 |
Progesterone |
Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor. |
Selective |
|
| S1304 |
Megestrol Acetate |
Megestrol acetate (BDH1298, SC10363) is a synthetic progestogen, used to treat breast cancer and loss of appetite. |
Selective |
|
